Introduction to INTRAROSA, an Endoceutics Discovery

INTRAROSA is not currently available in Canada.

Endoceutics has demonstrated the role of a very important, but previously unrecognized, source of sex steroids in women, dehydroepiandrosterone (DHEA), a compound inactive in itself but the precursor of many intracellular sex steroids.

In fact, after menopause, a time when the secretion of estrogens by the ovaries stops, the only source of estrogens and androgens becomes DHEA which is transformed intracellularly into estrogens and androgens in peripheral target tissues without biologically significant release of active estrogens or androgens in the blood. This achievement is due to the intracellular inactivation of the estrogens and androgens made from DHEA in the same cells where they are synthesized.

The DHEA serum levels markedly decrease with age

And the serum concentrations are highly variable between women, with levels ranging from barely detectable in some women to relatively high values or concentrations, similar to those seen before menopause, in other women.

The cessation of estrogen secretion by the ovaries at menopause is a normal phenomenon present in all women. Consequently, the biologically inactive concentration of estradiol in the circulation observed after menopause cannot explain why some women have menopausal symptoms, while others do not suffer from such symptoms. In fact, cessation of estrogen secretion by the ovaries is the same in all women and the serum concentration of estradiol is very low and biologically inactive in all women.

Consequently, since DHEA is the exclusive source of sex steroids after menopause, women with high serum DHEA can have no or minimal menopausal symptoms, while women with low DHEA are more likely to suffer from menopausal symptoms -- the lack of DHEA is thus the cause of the symptoms of menopause.

DHEA and the adrenal glands

DHEA is secreted mostly by the adrenal glands into the general circulation which distribute the inactive precursor molecule to all tissues where it is locally transformed intracellularly into precise and very small quantities of androgens and estrogens which permit a local control of cellular activity according to local needs. Since estrogens and androgens made intracellularly from DHEA are degraded locally, only the inactive degradation products are released in the blood for elimination by the liver and kidneys.

Non-estrogenic treatment of vulvovaginal atrophy: Intrarosa

Endoceutics has developed a non-estrogenic treatment for vulvovaginal atrophy. This treatment uses prasterone (DHEA), a compound without intrinsic estrogenic or androgenic activity which is transformed intracellularly into androgens and estrogens in the cells and vaginal layers physiologically in need of these sex steroids.

  • The approach discovered by Endoceutics is a non-estrogenic treatment for vulvovaginal atrophy .
  • Treatment of vulvovaginal atrophy is provided by a strictly local action in the vagina without exposure of the other tissues to estrogens or androgens.